Research Specialist B - Contract - Philadelphia, PA
Ready to help advance the next generation of engineered cell therapies for blood cancers while playing a pivotal role in a leading translational research laboratory?
探花合集 is seeking an experienced Research Specialist to join a large, collaborative translational research group of ~30 scientists working on engineered cellular therapies for blood cancers, including CAR T cells, CAR macrophages, and gene-edited hematopoietic stem cells.
This is a hybrid role, split roughly evenly between two functions:
Primary Responsibilities:
The successful candidate is someone with hands-on rodent experience who is seeking a stable, central role in a busy academic laboratory, including candidates building research experience before applying to graduate or medical school. Training will be provided on lab-specific models, imaging workflows, and operational systems.
Skills & Requirements:
- Experience with tumor xenograft or leukemia models, particularly in immunodeficient strains (NSG or similar)
- Experience with bioluminescent imaging (IVIS), bleeding, injection
- Familiarity with flow cytometry sample preparation or sterile cell culture
- Experience with laboratory purchasing, inventory systems, or electronic lab notebooks (e.g., Benching)
- Previous work in an academic or industry research laboratory
The Research Specialist B's responsibilities will be:
In Vivo Research Support (~50%)
- Perform routine mouse procedures, including but not limited to intravenous, intraperitoneal, subcutaneous, and retro-orbital injections; tumor cell and cell-therapy product administration; and compound dosing
- Collect blood by submandibular, retro-orbital, or terminal cardiac puncture; process serum and plasma; aspirate bone marrows
- Perform bioluminescent imaging (IVIS) to track tumor burden and cell trafficking, including luciferin administration, image acquisition, and quantification
- Conduct euthanasia and organ harvest (spleen, bone marrow, liver, lung, blood, tumor), and prepare single-cell suspensions for downstream flow cytometry and molecular analyses
- Monitor animal health and body condition, record clinical observations, and escalate concerns appropriately
- Support colony management in coordination with ULAR: cage census and record keeping
- Maintain meticulous, contemporaneous records in the electronic lab notebook and in study-specific data files
- Work strictly within approved IACUC protocols; assist with protocol amendments, animal ordering, and per-diem tracking
Laboratory Operations (~50%)
- Place and track orders for reagents, consumables, and equipment through Penn Marketplace and preferred vendors; reconcile packing slips, receipts, and invoices
- Maintain inventory of high-use consumables, media, sera, cytokines, and antibodies; establish par levels and reorder points so critical items never run out
- Receive, unpack, log, and appropriately store incoming shipments, including cold-chain and controlled items
- Monitor and maintain cold storage: ?80 掳C and ?20 掳C freezers, 4 掳C refrigerators, and liquid nitrogen vessels - including temperature logs, alarm response, defrost scheduling, LN2 fills, and coordination of service calls
- Maintain freezer and cryotank inventories and sample-location databases; support periodic cleanouts and consolidation
- Oversee shared equipment: routine maintenance, service contracts, calibration records, and coordination with vendors and core facilities
- Maintain lab safety and compliance: chemical inventory, SDS files, biohazard and sharps waste streams, autoclave use, and EHRS requirements
- Prepare common stock solutions, buffers, and media for shared lab use
- Help onboard and train new lab members on ordering procedures, storage systems, safety practices, and shared equipment
- Assist the Laboratory Manager with space organization, expense tracking, and general day-to-day operations
Required Qualifications
- Bachelor's degree in biology, biochemistry, neuroscience, animal science, or a related field
- 1-2 years of hands-on rodent experience, including injections, blood collection, and tissue harvest
- Willingness and ability to work with laboratory mice, including euthanasia and dissection
- Strong organizational skills, attention to detail, and reliable record keeping
- Ability to manage competing requests from multiple investigators and prioritize effectively
- Clear written and verbal communication; comfortable working as part of a large team
- Proficiency with standard office and data tools (Excel, email, shared drives)
- Ability to work independently and follow through on recurring responsibilities without prompting
If you are having difficulty in applying or if you have any questions, please contact
Mike Raletz at m.raletz@proclinical.com.
If you are interested in applying to this exciting opportunity, then please click 'Apply' or to speak to one of our specialists please request a call back at the top of this page.
探花合集 is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. 探花合集 is acting as an Employment Agency in relation to this vacancy.
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